Compile Data Set for Download or QSAR
Found 195 of ic50 data for polymerid = 9756
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences, Inc.

Curated by ChEMBL
LigandPNGBDBM50511450(CHEMBL4436749)copy SMILEScopy InChI
Affinity DataIC50: 0.0430nMAssay Description:Inhibition of human recombinant human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) using 8-oxo-dGTP as substrate incubated for 15 mins fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences, Inc.

Curated by ChEMBL
LigandPNGBDBM50511430(CHEMBL4455353)copy SMILEScopy InChI
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of human recombinant human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) using 8-oxo-dGTP as substrate incubated for 15 mins fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6PPZPubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences, Inc.

Curated by ChEMBL
LigandPNGBDBM50511431(CHEMBL4468099)copy SMILEScopy InChI
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of human recombinant human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) using 8-oxo-dGTP as substrate incubated for 15 mins fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6PPZPubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences, Inc.

Curated by ChEMBL
LigandPNGBDBM50511453(CHEMBL4451394)copy SMILEScopy InChI
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of human recombinant human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) using 8-oxo-dGTP as substrate incubated for 15 mins fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6PPZPubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences, Inc.

Curated by ChEMBL
LigandPNGBDBM50511452(CHEMBL4570266)copy SMILEScopy InChI
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of human recombinant human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) using 8-oxo-dGTP as substrate incubated for 15 mins fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6PPZPubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences, Inc.

Curated by ChEMBL
LigandPNGBDBM50548115(CHEMBL4778773)copy SMILES
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of MTH1 (unknown origin) using 8-oxo-dGTP as substrate preincubated for 15 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TB1BHRPubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences, Inc.

Curated by ChEMBL
LigandPNGBDBM50255581(CHEMBL4073623)copy SMILEScopy InChI
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human full length MTH1 using 8-Oxo-2-dGTP as substrate preincubated for 15 mins followed substrate addition measured after 1 hr by PPil...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25D8V9QPubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences, Inc.

Curated by ChEMBL
LigandPNGBDBM50255568(CHEMBL4091768)copy SMILEScopy InChI
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human full length MTH1 using 8-Oxo-2-dGTP as substrate preincubated for 15 mins followed substrate addition measured after 1 hr by PPil...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25D8V9QPubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences, Inc.

Curated by ChEMBL
LigandPNGBDBM50255622(CHEMBL4067896)copy SMILEScopy InChI
Affinity DataIC50: 0.100nMAssay Description:Binding affinity to recombinant human full length N-terminal His tagged-MTH1 expressed in Escherichia coli at 3 mM by isothermal titration calorimetr...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25D8V9QPubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences, Inc.

Curated by ChEMBL
LigandPNGBDBM50255621(CHEMBL4070624)copy SMILEScopy InChI
Affinity DataIC50: 0.100nMAssay Description:Binding affinity to recombinant human full length N-terminal His tagged-MTH1 expressed in Escherichia coli at 3 mM by isothermal titration calorimetr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25D8V9QPubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences, Inc.

Curated by ChEMBL
LigandPNGBDBM50255624(CHEMBL4101983)copy SMILEScopy InChI
Affinity DataIC50: 0.100nMAssay Description:Binding affinity to recombinant human full length N-terminal His tagged-MTH1 expressed in Escherichia coli at 3 mM by isothermal titration calorimetr...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25D8V9QPubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences, Inc.

Curated by ChEMBL
LigandPNGBDBM50255582(CHEMBL4078783)copy SMILEScopy InChI
Affinity DataIC50: 0.100nMAssay Description:Binding affinity to recombinant human full length N-terminal His tagged-MTH1 expressed in Escherichia coli at 3 mM by isothermal titration calorimetr...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25D8V9QPubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences, Inc.

Curated by ChEMBL
LigandPNGBDBM50255566(CHEMBL4094252)copy SMILEScopy InChI
Affinity DataIC50: 0.100nMAssay Description:Binding affinity to recombinant human full length N-terminal His tagged-MTH1 expressed in Escherichia coli at 3 mM by isothermal titration calorimetr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25D8V9QPubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences, Inc.

Curated by ChEMBL
LigandPNGBDBM50255598(CHEMBL4064004)copy SMILEScopy InChI
Affinity DataIC50: 0.100nMAssay Description:Binding affinity to recombinant human full length N-terminal His tagged-MTH1 expressed in Escherichia coli at 3 mM by isothermal titration calorimetr...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25D8V9QPubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences, Inc.

Curated by ChEMBL
LigandPNGBDBM50255603(CHEMBL4083992)copy SMILEScopy InChI
Affinity DataIC50: 0.100nMAssay Description:Binding affinity to recombinant human full length N-terminal His tagged-MTH1 expressed in Escherichia coli at 3 mM by isothermal titration calorimetr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25D8V9QPubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences, Inc.

Curated by ChEMBL
LigandPNGBDBM50511454(CHEMBL4460228)copy SMILEScopy InChI
Affinity DataIC50: 0.110nMAssay Description:Inhibition of human recombinant human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) using 8-oxo-dGTP as substrate incubated for 15 mins fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6PPZPubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences, Inc.

Curated by ChEMBL
LigandPNGBDBM50511432(CHEMBL4435945)copy SMILEScopy InChI
Affinity DataIC50: 0.150nMAssay Description:Inhibition of human recombinant human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) using 8-oxo-dGTP as substrate incubated for 15 mins fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6PPZPubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences, Inc.

Curated by ChEMBL
LigandPNGBDBM50511466(CHEMBL4529335)copy SMILEScopy InChI
Affinity DataIC50: 0.170nMAssay Description:Inhibition of human recombinant human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) using 8-oxo-dGTP as substrate incubated for 15 mins fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6PPZPubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences, Inc.

Curated by ChEMBL
LigandPNGBDBM50152144(CHEMBL3781661)copy SMILEScopy InChI
Affinity DataIC50: 0.200nMAssay Description:Inhibition of recombinant MTH1 (unknown origin) assessed as hydrolysis of 8-oxodGTP to 8-oxodGMP and pyrophosphate by PPiLight assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20K2BF6PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences, Inc.

Curated by ChEMBL
LigandPNGBDBM50152127(CHEMBL3780962)copy SMILEScopy InChI
Affinity DataIC50: 0.200nMAssay Description:Inhibition of recombinant MTH1 (unknown origin) assessed as hydrolysis of 8-oxodGTP to 8-oxodGMP and pyrophosphate by PPiLight assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20K2BF6PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences, Inc.

Curated by ChEMBL
LigandPNGBDBM50152144(CHEMBL3781661)copy SMILEScopy InChI
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human recombinant human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) using 8-oxo-dGTP as substrate incubated for 15 mins fo...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6PPZPubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences, Inc.

Curated by ChEMBL
LigandPNGBDBM50548110(CHEMBL4747532)copy SMILES
Affinity DataIC50: 0.300nMAssay Description:Inhibition of MTH1 (unknown origin) using 8-oxo-dGTP as substrate preincubated for 15 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TB1BHRPubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences, Inc.

Curated by ChEMBL
LigandPNGBDBM50511448(CHEMBL4460446)copy SMILEScopy InChI
Affinity DataIC50: 0.330nMAssay Description:Inhibition of human recombinant human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) using 8-oxo-dGTP as substrate incubated for 15 mins fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6PPZPubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences, Inc.

Curated by ChEMBL
LigandPNGBDBM50511428(CHEMBL4435983)copy SMILEScopy InChI
Affinity DataIC50: 0.490nMAssay Description:Inhibition of human recombinant human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) using 8-oxo-dGTP as substrate incubated for 15 mins fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6PPZPubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences, Inc.

Curated by ChEMBL
LigandPNGBDBM50548117(CHEMBL4776026)copy SMILES
Affinity DataIC50: 0.5nMAssay Description:Inhibition of MTH1 (unknown origin) using 8-oxo-dGTP as substrate preincubated for 15 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TB1BHRPubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences, Inc.

Curated by ChEMBL
LigandPNGBDBM50162075(CHEMBL3794167)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:Inhibition of MTH1 (unknown origin) using 8-oxo-dGTP as substrateMore data for this Ligand-Target Pair
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences, Inc.

Curated by ChEMBL
LigandPNGBDBM50152129(CHEMBL3780596)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:Inhibition of recombinant MTH1 (unknown origin) assessed as hydrolysis of 8-oxodGTP to 8-oxodGMP and pyrophosphate by PPiLight assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20K2BF6PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences, Inc.

Curated by ChEMBL
LigandPNGBDBM50162075(CHEMBL3794167)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:Inhibition of MTH1 (unknown origin) using 8-oxo-dGTP as substrate preincubated for 15 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences, Inc.

Curated by ChEMBL
LigandPNGBDBM50162074(CHEMBL3792684)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:Inhibition of MTH1 (unknown origin) using 8-oxo-dGTP as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VX0JDPPubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences, Inc.

Curated by ChEMBL
LigandPNGBDBM50162074(CHEMBL3792684)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:Inhibition of MTH1 (unknown origin) using 8-oxo-dGTP as substrate preincubated for 15 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TB1BHRPubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences, Inc.

Curated by ChEMBL
LigandPNGBDBM50152130(CHEMBL3780613)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:Inhibition of recombinant MTH1 (unknown origin) assessed as hydrolysis of 8-oxodGTP to 8-oxodGMP and pyrophosphate by PPiLight assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20K2BF6PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences, Inc.

Curated by ChEMBL
LigandPNGBDBM50152145(CHEMBL3780032)copy SMILEScopy InChI
Affinity DataIC50: 0.600nMAssay Description:Inhibition of recombinant MTH1 (unknown origin) assessed as hydrolysis of 8-oxodGTP to 8-oxodGMP and pyrophosphate by PPiLight assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20K2BF6PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences, Inc.

Curated by ChEMBL
LigandPNGBDBM50511463(CHEMBL4577002)copy SMILEScopy InChI
Affinity DataIC50: 0.610nMAssay Description:Inhibition of human recombinant human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) using 8-oxo-dGTP as substrate incubated for 15 mins fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6PPZPubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences, Inc.

Curated by ChEMBL
LigandPNGBDBM50511457(CHEMBL4537820)copy SMILEScopy InChI
Affinity DataIC50: 0.700nMAssay Description:Inhibition of human recombinant human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) using 8-oxo-dGTP as substrate incubated for 15 mins fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6PPZPubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences, Inc.

Curated by ChEMBL
LigandPNGBDBM50152125(CHEMBL3781316)copy SMILEScopy InChI
Affinity DataIC50: 0.800nMAssay Description:Inhibition of recombinant human MTH1 assessed as hydrolysis of dGTP to dGMP and pyrophosphate after 15 mins by malachite green-based microplate reade...More data for this Ligand-Target Pair
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences, Inc.

Curated by ChEMBL
LigandPNGBDBM50152125(CHEMBL3781316)copy SMILEScopy InChI
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human recombinant human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) using dGTP as substrate measured after 30 mins by mala...More data for this Ligand-Target Pair
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences, Inc.

Curated by ChEMBL
LigandPNGBDBM50255583(CHEMBL4096813)copy SMILEScopy InChI
Affinity DataIC50: 0.800nMAssay Description:Binding affinity to recombinant human full length N-terminal His tagged-MTH1 expressed in Escherichia coli at 3 mM by isothermal titration calorimetr...More data for this Ligand-Target Pair
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences, Inc.

Curated by ChEMBL
LigandPNGBDBM50152125(CHEMBL3781316)copy SMILEScopy InChI
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) in presence of dGTP and inorganic pyrophosphatase incubated for 15 mins ...More data for this Ligand-Target Pair
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences, Inc.

Curated by ChEMBL
LigandPNGBDBM50511439(CHEMBL4565830)copy SMILEScopy InChI
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human recombinant human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) using 8-oxo-dGTP as substrate incubated for 15 mins fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences, Inc.

Curated by ChEMBL
LigandPNGBDBM50548124(CHEMBL4784602)copy SMILES
Affinity DataIC50: 0.800nMAssay Description:Inhibition of MTH1 (unknown origin) using 8-oxo-dGTP as substrate preincubated for 15 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TB1BHRPubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences, Inc.

Curated by ChEMBL
LigandPNGBDBM50511458(CHEMBL4534555)copy SMILEScopy InChI
Affinity DataIC50: 0.820nMAssay Description:Inhibition of human recombinant human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) using 8-oxo-dGTP as substrate incubated for 15 mins fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6PPZPubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences, Inc.

Curated by ChEMBL
LigandPNGBDBM50152125(CHEMBL3781316)copy SMILEScopy InChI
Affinity DataIC50: 0.900nMAssay Description:Inhibition of MTH1 (unknown origin) using 8-oxo-dGTP as substrateMore data for this Ligand-Target Pair
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences, Inc.

Curated by ChEMBL
LigandPNGBDBM50548109(CHEMBL4783492)copy SMILES
Affinity DataIC50: 0.900nMAssay Description:Inhibition of MTH1 (unknown origin) using 8-oxo-dGTP as substrate preincubated for 15 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences, Inc.

Curated by ChEMBL
LigandPNGBDBM50255623(CHEMBL4072758)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Binding affinity to recombinant human full length N-terminal His tagged-MTH1 expressed in Escherichia coli at 3 mM by isothermal titration calorimetr...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25D8V9QPubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences, Inc.

Curated by ChEMBL
LigandPNGBDBM50511441(CHEMBL4464305)copy SMILEScopy InChI
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human recombinant human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) using 8-oxo-dGTP as substrate incubated for 15 mins fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6PPZPubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences, Inc.

Curated by ChEMBL
LigandPNGBDBM50548121(CHEMBL4754128)copy SMILES
Affinity DataIC50: 1.40nMAssay Description:Inhibition of MTH1 (unknown origin) using 8-oxo-dGTP as substrate preincubated for 15 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TB1BHRPubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences, Inc.

Curated by ChEMBL
LigandPNGBDBM50152125(CHEMBL3781316)copy SMILEScopy InChI
Affinity DataIC50: 1.60nMAssay Description:Inhibition of recombinant MTH1 (unknown origin) assessed as hydrolysis of 8-oxodGTP to 8-oxodGMP and pyrophosphate by PPiLight assayMore data for this Ligand-Target Pair
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences, Inc.

Curated by ChEMBL
LigandPNGBDBM50152126(CHEMBL3780321)copy SMILEScopy InChI
Affinity DataIC50: 1.80nMAssay Description:Inhibition of recombinant MTH1 (unknown origin) assessed as hydrolysis of 8-oxodGTP to 8-oxodGMP and pyrophosphate by PPiLight assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20K2BF6PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences, Inc.

Curated by ChEMBL
LigandPNGBDBM50255585(CHEMBL4094381)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Binding affinity to recombinant human full length N-terminal His tagged-MTH1 expressed in Escherichia coli at 3 mM by isothermal titration calorimetr...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25D8V9QPubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences, Inc.

Curated by ChEMBL
LigandPNGBDBM50548119(CHEMBL4749068)copy SMILES
Affinity DataIC50: 2nMAssay Description:Inhibition of MTH1 (unknown origin) using 8-oxo-dGTP as substrate preincubated for 15 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TB1BHRPubMed
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